Millions of workers worldwide are exposed to organic solvents that are used in such products as paints, varnishes, lacquers, adhesives, glues, and degreasing/cleaning agents, and in the production of dyes, polymers, plastics, textiles, printing inks, agricultural products, and pharmaceuticals. The results of the studies performed to study the effect of exposure to organic solvents on kidney in workers occupationally exposed to organic solvents over the last twenty years are contradictory. This book presents an analytical study of the effect of occupational exposure to organic solvents on renal functions using both routine renal function tests namely; serum urea, serum creatinine, estimated glomerular filtration rate and early renal urinary biomarkers namely; N acetyl-B-D glucosaminidase and B2 microglobulin. This book provides an evidence of the potential role of exposure to mixture of organic solvents in impairing the renal functions.