The thyroid hormones play a pivotal role in the generation of oxidative stress on exposure to stressor. It was further observed that vitamin E treatment eliminated the stress induced oxidative stress while the raised levels of T3 and T4 remained unaffected.The present investigations provided enough evidence to show that the supra spinal response to stress basically elevates the thyroid hormone levels, which onward causes the oxidative stress. Such conclusion further suggests the use of antithyroid agent to prevent the stress induced oxidative stress and subsequent tissue degeneration. However, it is cautioned that the levels of thyroid hormones must be first assessed in stressed exposed subjects before any antithyroid agent is used to prevent the oxidative stress as the hypothyroidism after the inappropriate dose of antithyroid agent is likely to impair the stress- sustainace ability.