Rise of antibiotic resistant bacteria is a global health concern rapidly increasing in its magnitude.Hospitals represent a critical component of the antimicrobial resistance problem worldwide.This book contain sections about the epidemiology of antibiotic resistance,how antibacterial drug resistance occurs, types and mechanisms of antimicrobial resistance, the genetic elements and the transfer of antibiotic resistance between animal and man. Laboratory techniques used to detect antibiotic resistance, prevention and control of antibiotic resistance, important infections associated with bacterial drug resistance. Antimicrobial agents, Antiseptics and disinfectants and their role in antibiotic resistance.This work oriented to health care professionals, and medical researchers so as to encourage research in clinical settings.