Background: Automated peritoneal dialysis (APD) is peritoneal dialysis (PD) using cycler machines which can deliver predetermined volumes of dialysate into the peritoneal cavity and then drain it after a programmed dwell time. Anochie and eke (2006) reported that one of the advantages of APD is adequacy of dialysis. Objective: To determine the effectiveness of APD in the management of acute renal failure (ARF) in Kenya. Design: A retrospective cohort study Setting:Setting: Kenyatta National Hospital (KNH), Gertrude children’s Hospital, Aga khan hospital Nairobi, Mater hospital and Nairobi west Hospital.Subjects: The study population was children and adults with ARF who were put on APD from may 2006 –may 2010. Results: The mean Serum Creatinine, Blood Urea Nitrogen (BUN), Serum Potassium prior to APD was comparatively higher than the mean on APD discontinuation, discharge or death. The mean 24-hour urine output prior to APD was 100.8 and after APD discontinuation was 482.5 which were quite significant. The mortality rate was 37% (n=13) while survival rate was 63% (n=22) where patients were treated and discharged.