A combinatorial approach in metal cytotoxic mechanisms condenses the diffuse literature on metal toxicology into an accessible and readable text. It introduces fundamental concepts in mechanistic toxicology and use a functionomic approach to understand the heavy metals cytotoxic mechanism, e.g., the effects of inhibitors or substrates of metabolizing enzyme/transporting pathway and other cellular vital pathways on the loss of cell viability and oxidative stress markers induced by the heavy metals. A combinatorial approach in metal cytotoxic mechanisms will be invaluable for students and teachers of toxicology and also for those such as environmental scientists, biologists, chemists / chemical engineers or even legislators working in related area. For these groups the book provides a comprehensive and practical introduction to the whole subject.