Meningiomas represent about 15% of all intracranial neoplasm, and are generally extra-axial and benign, but in more than 50% are accompanied by PTE which can increase the difficulty of surgical resection and affect the prognosis after surgical treatment. Increased expression of vascular endothelial growth factor (VEGF) plays significant role in meningioma hypervascularity and PTE genesis that also influences the prognosis in surgically treated patients. The aim of our study was to investigate the influence of peritumoral edema and angiogenesis (VEGF expression), microvascular density, and proliferative cell potential on prognosis in aspect of morbidity and postoperative complications after intracranial meningioma surgery. The analysis of clinical, neuroradiological, and histological data of microsurgically treated patients with intracranial supratentorial meningioma was performed. Results of study showed that peritumoral edema in intracranial meningiomas has significant influence on prognosis in surgically treated patients. VEGF expression is strongly correlated with PTE formation and strongly affects the outcome of treatment.