The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time,Q 6h,Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for...
Сделать выводы о внешнем виде ос, возраст которых равен 99 миллионам лет, позволила просветка с помощью микроскопа трех десятков кусочков янтаря, который относится к меловому периоду. Камни были обнаружены на севере Мьянмы.
Китайским палеонтологам удалось узнать, как выглядели насекомые возрастом около 99 миллионов лет. Для этого они использовали электронный микроскоп, через который просветили 30 найденных на севере Мьянмы кусочков янтаря времен данного периода.