Currently, there is great interest in incorporating biological information into intensity-modulated radiotherapy (IMRT) treatment planning with the aim of selectively boosting high-risk tumor subvolumes – a concept that has also been called ‘dose painting’. However, conventional IMRT optimization utilizes dose-volume based objective functions, which have inherent limitations such as pursuing homogeneous dose distributions and assuming linear-dose-response curves. In this book we present a dose painting IMRT optimization-framework in which nonlinear biological objective functions are utilized. Prostate cancer has been used as a model system to explore its feasibility. The impact of functional imaging accuracy such as sensitivity and specificity on dose painting IMRT is subsequently presented. A comparison study between dose painting IMRT strategies and uniform-boosting IMRT strategies yielding the same EUD to the overall PTV is also presented. A novel dose painting IMRT strategy using biological parameters is proposed and promises increased expected local control for locoregionally advanced tumors with equivalent or better normal tissue sparing.
Что такое "закон Димы Яковлева". Полный текст закона
Что такое "закон Димы Яковлева"? Государственная дума РФ приняла закон-ответ на "акт Магнитского" принятый в США, который запрещает усыновление российских детей гражданами США. Закон "О мерах воздействия на лиц, причастных к нарушениям основополагающих прав и свобод человека, прав и свобод граждан Российской Федерации", получил название - "закон Димы Яковлева".