Neurological diseases are a global burden, with huge consequences both in mortality and morbidity. Research efforts towards the search for neuroprotective substances in hopes to curtailing the consequences of these diseases are continuous. Most neurodegenrative diseases are usually a consequence of excess production of oxygen radicals from oxidative stress. The oxygen radicals are mopped up by antioxidants produced endogenously or from nutritional supplements. Flavonoids are rich sources of antioxidants. Thus have the ability to scavenge free radicals, making them harmless. There are abundant plants known to be rich in antioxidants. Kolaviron is the biflavonoid complex and most abundant constituent of one of such plants, Garcinia kola. Due to the antioxidant properties of kolaviron it will have the potential to protect neurons from toxic damage, and that is the focus of this work. Also this work hopes to encourage more researches amongst bio-medical scientists in search for more neuroprotective plant sources as these may make a key contribution to controlling and curtailing neurological diseases.