A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.
Зная школьную нелюбовь к посещению уроков физкультуры, во многих вузах студентам этот предмет может сыграть не самую последнюю роль. Те, кто активно занимаются спортом, отстаивают честь заведения на городских, российских или даже международных состязаниях, находятся на особом счету.