The liver which is the major organ in the body, where drugs get metabolized and detoxified, is subject to potential damage from the pharmaceutical and environmental chemicals. Many of the widely used therapeutic drugs, including over the counter drugs can cause hepatic injury. Of the numerous remedies, medicinal agents, chemicals and herbal remedies in existence, more than 600 are recognized as being capable of producing hepatic injury. So effective agents are required for the prevention of hepatic injury caused by hepatotoxic drugs and chemicals. The objectives of this book is to study the hepatoprotective effect of aqueous extract of Azadirachta indica leaves on paracetamol induced hepatotoxicity in albino rats. Aqueous extract of Azadirachta indica leaves provides hepatoprotective effect on paracetamol induced hepatotoxicity in rats, as evidenced by significant difference in biochemical parameters and histopathological study. The efficacy of hepatoprotective effect of aqueous extract of Azadirachta indica leaves is less when compared to silymarin, as evidenced by significant difference in biochemical parameters.