Multiple sclerosis (MS) is an immune mediated, inflammatory demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of MS. MS is considered as one of the most important causes of disability in adults. It is a chronic progressive, potentially disabling disorder with considerable social impact and economic consequences. Unfortunately, it is not currently possible to cure MS, the treatments available up to now have centered their action on the anti-inflammatory and disease course-modifying effect, and the purpose of treatment is to prevent recurrence of relapses and accumulation of disability. In addition, all the approved drugs for MS treatment have potentially serious side effects.Therefore the aim of the present study was to investigate the protective as well as the possible ameliorative effects of N. sativa seeds (a natural non-toxic product) in EAE-induced Wistar female rats.