Hepatic damage is a major problem due to Viruses, Xenobiotics, toxic chemicals, environmental pollutants, contaminated water supplies and surface water can cause liver problems. Some harmful chemicals are also responsible for the hepatic fibrosis like CCl4, thioacetamide etc. The cure for this disease is not well established till now. Functionally liver is a detoxifying organ converts ammonia into urea through ornithine cycle because ammonia is highly toxic to the animal body. Present work gives information to promote the alternative herbal products rather than harmful chemo-therapeutics. Therapeutic role of two well known herbal components Picroliv from the roots of Picrorhiza kurroa and Andrographolide from the leaves of Andrographis Paiculata were used to cure the hepatic fibrosis in rats induced by administration of Thioacetamide which cause severe liver damage. Results represents the effective role of these plant components in curing Hepatic fibrosis without produce stress by itself.